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alteration of blood–brain barrier integrity by retroviral infection改变血脑屏障完整性的逆转录病毒感染
Alteration of Blood–Brain Barrier Integrity by Retroviral
Infection
1 1 2 3 4
Philippe V. Afonso , Simona Ozden , Marie-Christine Cumont , Danielle Seilhean , Luis Cartier , Payam
5 5 6 2 1 6
Rezaie , Sarah Mason , Sophie Lambert , Michel Huerre , Antoine Gessain , Pierre-Olivier Couraud ,
Claudine Pique6, Pierre-Emmanuel Ceccaldi1.*, Ignacio A. Romero1,5.*
´ ´ ` ´
1 Unite d’Epidemiologie et Physiopathologie des Virus Oncogenes, CNRS URA3015, Institut Pasteur, Paris, France, 2 Unite de Recherche et d’Expertise Histotechnologie et
ˆ ˆ `
Pathologie, Institut Pasteur, Paris, France, 3 Laboratoire de Neuropathologie, Hopital de la Salpetriere, Paris, France, 4 Facultad de Medicina, Universidad de Chile, Santiago
´
de Chile, Chile, 5 Department of Life Sciences, The Open University, Milton Keynes, United Kingdom, 6 Departement de Biologie Cellulaire, CNRS 8104/INSERM 567/Paris V,
Institut Cochin, Paris, France
Abstract
The blood–brain barrier (BBB), which forms the interface between the blood and the cerebral parenchyma, has been shown
to be disrupted during retroviral-associated neuromyelopathies. Human T Lymphotropic Virus (HTLV-1) Associated
Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a slowly progressive neurodegenerative disease associated wi
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