alteration of micrornas regulated by c-myc in burkitt lymphoma小分子核糖核酸的改变由原癌基因在伯基特淋巴瘤.pdfVIP

Alteration of MicroRNAs Regulated by c-Myc in Burkitt Lymphoma 1 1 1 1 1 Anna Onnis , Giulia De Falco , Giuseppina Antonicelli , Monica Onorati , Cristiana Bellan , Omar 2 2 1 Sherman , Shaheen Sayed , Lorenzo Leoncini * 1 Department of Human Pathology and Oncology, University of Siena, Siena, Italy, 2 Aga Khan Hospital, Nairobi, Kenya Abstract Background: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma, with a characteristic clinical presentation, morphology and immunophenotype. Over the past years, the typical translocation t(8;14) and its variants have been considered the molecular hallmark of this tumor. However, BL cases with no detectable MYC rearrangement have been identified. Intriguingly, these cases express MYC at levels comparable with cases carrying the translocation. In normal cells c-Myc expression is tightly regulated through a complex feedback loop mechanism. In cancer, MYC is often dysregulated, commonly due to genomic abnormalities. It has recently emerged that this phenomenon may rely on an alteration of post-transcriptional regulation mediated by microRNAs (miRNAs), whose functional alterations are associated with neoplastic transformation. It is also emerging that c-Myc modulates miRNA expression, revealing an intriguing crosstalk between c-Myc and miRNAs. Principal Findings: Here, we investigated the expression of miRNAs possibly regulated by c-Myc in BL cases positive or negative for the translocation. A common trend of miRNA expression, with the exception of hsa-miR-9*, was observed in all of the cases. Intriguingly, down-regulation of this miRNA seems to specifically identify a particular subset of BL cases, lacki