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allele-biased expression in differentiating human neurons implications for neuropsychiatric disordersallele-biased表达式在区分人类神经元对神经精神障碍的影响.pdf

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allele-biased expression in differentiating human neurons implications for neuropsychiatric disordersallele-biased表达式在区分人类神经元对神经精神障碍的影响

Allele-Biased Expression in Differentiating Human Neurons: Implications for Neuropsychiatric Disorders 1 2 2 3 1,4,5 Mingyan Lin , Anastasia Hrabovsky , Erika Pedrosa , Tao Wang , Deyou Zheng , Herbert M. Lachman1,2,4,6* 1 Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, United States of America, 3 Department of Epidemiology Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America, 4 Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America, 5 Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, United States of America, 6 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America Abstract Stochastic processes and imprinting, along with genetic factors, lead to monoallelic or allele-biased gene expression. Stochastic monoallelic expression fine-tunes information processing in immune cells and the olfactory system, and imprinting plays an important role in development. Recent studies suggest that both stochastic events and imprinting may be more widespread than previously considered. We are interested in allele-biased gene expression occurring in the brain because parent-of-origin effects suggestive of imprinting appear to play a role in the transmission of schizophrenia (SZ) and autism spectrum disorders (ASD) in some families. In addition, allele-biased expression could help explain monozygotic (MZ) twin discordance and reduced