有哪些信誉好的足球投注网站allelic lineages of the ficolin genes (fcns) are passed from ancestral to descendant primatesficolin基因的等位基因血统(fcns)从祖先传给后代灵长类动物.pdfVIP
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allelic lineages of the ficolin genes (fcns) are passed from ancestral to descendant primatesficolin基因的等位基因血统(fcns)从祖先传给后代灵长类动物
Allelic Lineages of the Ficolin Genes (FCNs) Are Passed
from Ancestral to Descendant Primates
1. 1. 1 2 3
Tina Hummelshøj , Janna Nissen , Lea Munthe-Fog , Claus Koch , Mads Frost Bertelsen , Peter
Garred1*
1 Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark,
2 Department of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark, 3 Center for Zoo and Wild Animal Health,
Copenhagen Zoo, Frederiksberg, Denmark
Abstract
The ficolins recognize carbohydrates and acetylated compounds on microorganisms and dying host cells and are able to
activate the lectin pathway of the complement system. In humans, three ficolin genes have been identified: FCN1, FCN2 and
FCN3, which encode ficolin-1, ficolin-2 and ficolin-3, respectively. Rodents have only two ficolins designated ficolin-A and
ficolin-B that are closely related to human ficolin-1, while the rodent FCN3 orthologue is a pseudogene. Ficolin-2 and ficolin-
3 have so far only been observed in humans. Thus, we performed a systematic investigation of the FCN genes in non-human
primates. The exons and intron-exon boundaries of the FCN1-3 genes were sequenced in the following primate species:
chimpanzee, gorilla, orangutan, rhesus macaque, cynomolgus macaque, baboon and common marmoset. We found that
the exon organisation of the FCN genes was very similar between all the non-human primates and the human FCN genes.
Several variations in the FCN genes were found in more than one primate specie suggesting that they were carried from one
species to another including humans. The amino acid diversity of the ficolins among human and
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