有哪些信誉好的足球投注网站allelic diversity of the plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopes等位基因多样性的恶性疟原虫红细胞膜蛋白1需要variant-specific红细胞表面抗原表位.pdfVIP
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allelic diversity of the plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopes等位基因多样性的恶性疟原虫红细胞膜蛋白1需要variant-specific红细胞表面抗原表位
Allelic Diversity of the Plasmodium falciparum
Erythrocyte Membrane Protein 1 Entails Variant-Specific
Red Cell Surface Epitopes
` 1,2 1,2 3,4 1,2
Ines Vigan-Womas , Micheline Guillotte , Alexandre Juillerat , Cindy Vallieres , Anita
3,4 5 5 3,4 1,2
Lewit-Bentley , Adama Tall , Laurence Baril , Graham A. Bentley , Odile Mercereau-Puijalon *
´ ´ ´
1 Institut Pasteur, Unite d’Immunologie Moleculaire des Parasites, Paris, France, 2 CNRS URA 2581, Paris, France, 3 Institut Pasteur, Unite d’Immunologie Structurale, Paris,
´ ´ ´ ´
France, 4 CNRS URA 2185, Paris, France, 5 Unite d’Epidemiologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal
Abstract
The clonally variant Plasmodium falciparum PfEMP1 adhesin is a virulence factor and a prime target of humoral immunity. It
is encoded by a repertoire of functionally differentiated var genes, which display architectural diversity and allelic
polymorphism. Their serological relationship is key to understanding the evolutionary constraints on this gene family and
rational vaccine design. Here, we investigated the Palo Alto/VarO and IT4/R29 and 3D7/PF13_003 parasites lines. VarO and
R29 form rosettes with uninfected erythrocytes, a phenotype associated with severe malaria. They express an allelic Cys2/
group A NTS-DBL1a
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