有哪些信誉好的足球投注网站acute activation of amp-activated protein kinase prevents h2o2-induced premature senescence in primary human keratinocytes急性活化蛋白激酶的激活可以防止h2o2-induced过早衰老的主要人类角质细胞.pdfVIP
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acute activation of amp-activated protein kinase prevents h2o2-induced premature senescence in primary human keratinocytes急性活化蛋白激酶的激活可以防止h2o2-induced过早衰老的主要人类角质细胞
Acute Activation of AMP-Activated Protein Kinase
Prevents H O -Induced Premature Senescence in
2 2
Primary Human Keratinocytes
1 2 1 1 1 2
Yasuo Ido *, Albert Duranton , Fan Lan , Jose M. Cacicedo , Tai C. Chen , Lionel Breton ,
Neil B. Ruderman1*
1 Section of Endocrinology and Diabetes Research Unit, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America,
2 L’OREAL Recherche, Centre Charles Zviak, Clichy, France
Abstract
We investigated the effects of AMPK on H O -induced premature senescence in primary human keratinocytes. Incubation
2 2
with 50 mM H O for 2 h resulted in premature senescence with characteristic increases in senescence-associated ß-
2 2
galactosidase (SA-gal) staining 3 days later and no changes in AMPK or p38 MAPK activity. The increase in SA-gal staining
was preceded by increases in both p53 phosphorylation (S15) (1 h) and transactivation (6 h) and the abundance of the
cyclin inhibitor p21CIP1 (16 h). Incubation with AICAR or resveratrol, both of which activated AMPK, prevented the H O -
2 2
induced increases in both SA-Gal staining and p21 abundance. In addition, AICAR diminished the increase in p53
transactivation. The decreases in SA-Gal expression induced by resveratrol and AICAR were prevented by the
pharmacological AMPK inhibitor Compound C, expression of a DN-AMP
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