有哪些信誉好的足球投注网站acute hcvhiv coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation急性hcvhiv合并感染与认知功能障碍和脑代谢障碍有关,但不增加小胶质细胞的激活.pdfVIP
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acute hcvhiv coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation急性hcvhiv合并感染与认知功能障碍和脑代谢障碍有关,但不增加小胶质细胞的激活
Acute HCV/HIV Coinfection Is Associated with Cognitive
Dysfunction and Cerebral Metabolite Disturbance, but
Not Increased Microglial Cell Activation
1,2 3 3 1,2 4
Lucy J. Garvey *, Nicola Pavese , Anil Ramlackhansingh , Emma Thomson , Joanna M. Allsop ,
3 5 1,2 3 1
Marios Politis , Ranjababu Kulasegaram , Janice Main , David J. Brooks , Simon D. Taylor-Robinson ,
Alan Winston1,2
1 Department of Medicine, Imperial College London, London, United Kingdom, 2 Department of HIV and GU Medicine, Imperial College Healthcare NHS Trust, London,
United Kingdom, 3 Neurosciences Section, Division of Experimental Medicine, Imperial College London, London, United Kingdom, 4 Imaging Sciences Department,
Medical Research Council (MRC) Clinical Sciences Centre, Imperial College London, London, United Kingdom, 5 Department of HIV and GU Medicine, Guy’s and St Thomas’
NHS Foundation Trust, London, United Kingdom
Abstract
Background: Microglial cell activation and cerebral function impairment are described in both chronic hepatitis C viral (HCV)
and Human-Immune-Deficiency viral (HIV) infections. The aim of this study was to investigate the effect of acute HCV
infection upon cerebral function and microglial cell activation in HIV-infected individuals.
Methods: A case-control study was conducted. Subjects with acute HCV and chronic HIV coinfection (aHCV) were compared
to matched controls with chronic HIV monoinfection (HIVmono). aHCV was defined as a new positive plasma HCV RNA
within 12 months of a negative RNA
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