有哪些信誉好的足球投注网站allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to bacillus anthracis等位基因变异在小鼠染色体11日修改主机炎症反应和抗炭疽杆菌.pdfVIP
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allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to bacillus anthracis等位基因变异在小鼠染色体11日修改主机炎症反应和抗炭疽杆菌
Allelic Variation on Murine Chromosome 11 Modifies
Host Inflammatory Responses and Resistance to Bacillus
anthracis
1 1 2 2 2 2
Jill K. Terra , Bryan France , Christopher K. Cote , Amy Jenkins , Joel A. Bozue , Susan L. Welkos , Ragini
1 1 3 3 1,3,4 4
Bhargava , Chi-Lee Ho , Margarete Mehrabian , Calvin Pan , Aldons J. Lusis , Richard C. Davis ,
5 1
Steven M. LeVine , Kenneth A. Bradley *
1 Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, United States of America,
2 Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, United States of America, 3 Department
of Human Genetics, University of California at Los Angeles, Los Angeles, California, United States of America, 4 Department of Medicine, University of California at Los
Angeles, Los Angeles, California, United States of America, 5 Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas,
United States of America
Abstract
Anthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced
by pathogen-encoded virulence factors such as lethal toxin (LT), as well as by genetic variation within the host. To identify
host genes controlling susceptibility to anthrax, a library of congenic mice consisting of strains with homozygous
chromosomal segments from the LT-responsive CAST/Ei stra
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