acute oral toxicity evaluations of some zinc(ii) complexes derived from 1-(2-salicylaldiminoethyl)piperazine schiff bases in rats急性口服毒性评价的锌(ii)配合物来自1 -(2-salicylaldiminoethyl)哌嗪希夫碱在大鼠.pdfVIP

Int. J. Mol. Sci. 2012, 13, 1393-1404; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Acute Oral Toxicity Evaluations of Some Zinc(II) Complexes Derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff Bases in Rats Muhammad Saleh Salga 1,*, Hapipah Mohd Ali 1, Mahmood Ameen Abdulla 2 and 3 Siddig Ibrahim Abdelwahab 1 Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail: hapipah@.my 2 Department of Molecular Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail: mahmood955@ 3 Department of Pharmacy, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail: siddigroa@.my * Author to whom correspondence should be addressed; E-Mail: salgamohd@; Tel./Fax: +60-126155723. Received: 22 December 2011; in revised form: 12 January 2012 / Accepted: 13 January 2012 / Published: 27 January 2012 Abstract: The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, 1H NMR, 13C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, m