acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin d3 levels in male mice急性erythemal紫外辐射导致缺乏系统性免疫抑制雄性老鼠体内25 -羟维生素d3水平增加.pdfVIP

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acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin d3 levels in male mice急性erythemal紫外辐射导致缺乏系统性免疫抑制雄性老鼠体内25 -羟维生素d3水平增加.pdf

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acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin d3 levels in male mice急性erythemal紫外辐射导致缺乏系统性免疫抑制雄性老鼠体内25 -羟维生素d3水平增加

Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25- Hydroxyvitamin D3 Levels in Male Mice 1 1 1 1 2 Shelley Gorman *, Naomi M. Scott , Daryl H. W. Tan , Clare E. Weeden , Robert C. Tuckey , 1 3 1 Jacqueline L. Bisley , Michele A. Grimbaldeston , Prue H. Hart 1Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Aust ralia, 2 School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia. Perth, Western Australia, Australia, 3 Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia Abstract Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator of the immunosuppression that occurs following UV radiation (UVR) exposure. Both UVR and vitamin D drive immune responses towards tolerance by ultimately increasing the suppressive activities of regulatory T cells. To examine a role for UVR-induced vitamin D, vitamin D -deficient mice were established by dietary vitamin D restriction. In comparison to vitamin D -replete 3 3 3 mice, vitamin D -deficient mice had significantly reduced serum levels of 25-hydroxyvitamin D (25(OH)D , ,20 nmol.L21) 3 3