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acute exposure of apigenin induces hepatotoxicity in swiss mice芹黄素的急性照射诱发肝毒性在瑞士老鼠
Acute Exposure of Apigenin Induces Hepatotoxicity in
Swiss Mice
Prabhat Singh, Shrawan Kumar Mishra, Sanjeev Noel, Sharad Sharma, Srikanta Kumar Rath*
Division of Toxicology, Central Drug Research Institute (CSIR), Lucknow, India
Abstract
Apigenin, a dietary flavonoid, is reported to have several therapeutic effects in different diseases including cancer. Toxicity
of Apigenin is however, least explored, and reports are scanty in literature. This warrants dose-specific evaluation of toxicity
in vivo. In the present study, Apigenin was administered intraperitoneally to Swiss mice at doses of 25, 50, 100 and 200 mg/
kg. Serum levels of alanine amino transferase (ALT), aspartate amino transferase (AST) and alkaline phosphatase (ALP) were
measured along with the examination of liver histology, reactive oxygen species (ROS) in blood, lipid peroxidation (LPO),
glutathione level, superoxide dismutase activity, catalase activity, glutathione S-transferase activity and gene expression in
liver tissue. Increase in ALT, AST, ALP, ROS, ratio of oxidized to reduced glutathione (GSSG/GSH) and LPO, altered enzyme
activities along with damaged histoarchitecture in the liver of 100 or 200 mg/kg Apigenin treated animals were found.
Microarray analysis revealed the differential expression of genes that correspond to different biologically relevant pathways
including oxidative stress and apoptosis. In conclusion, these results suggested the oxidative stress induced liver damage
which may be due to the regulation of multiple genes by Apigenin at higher doses in Swiss mice.
Citation: Singh P, Mishra SK, Noel S, Sharma S, Rath SK (2012) Acute Exposure of Apigenin Induces Hepatotoxicity in Swiss Mice. PLoS ONE 7(2): e31964.
doi:10.1371/journal.pone.0031964
Editor: Aamir Ahmad, Wayne State University School of Medicine, United States of America
Received Septembe
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