有哪些信誉好的足球投注网站acute myeloid leukemia (aml) with erythroid predominance exhibits clinical and molecular characteristics that differ from other types of aml急性髓系白血病(aml)与红细胞优势展品临床和分子特征不同于其他类型的aml.pdfVIP
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acute myeloid leukemia (aml) with erythroid predominance exhibits clinical and molecular characteristics that differ from other types of aml急性髓系白血病(aml)与红细胞优势展品临床和分子特征不同于其他类型的aml
Acute Myeloid Leukemia (AML) with Erythroid
Predominance Exhibits Clinical and Molecular
Characteristics that Differ from Other Types of AML
¤
Zhuang Zuo*, L. Jeffrey Medeiros, Zhao Chen, Dingsheng Liu , Carlos E. Bueso-Ramos,
Rajyalakshmi Luthra, Sa A.Wang
Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
Abstract
The clinical importance of erythroid predominance in bone marrow of patients with acute myeloid leukemia (AML) is
controversial. These cases represent a heterogeneous group of diseases that historically have been classified into different
categories. We studied 313 AML patients and specifically compared the clinical, cytogenetic, and molecular features of cases
of AML with erythroid predominance, arbitrarily defined as $50% erythroid precursors, to AML cases without erythroid
predominance. We also assessed 51 patients with a high-grade myelodysplastic syndrome (MDS), refractory anemia with
excess blasts (RAEB). All neoplasms were classified according to the World Health Organization classification. With the
exception of therapy-related AML/MDS, the presence of erythroid predominance in variously classified categories of AML
was associated with a survival advantage. In addition, AML with erythroid predominance had a lower frequency of
cytogenetic abnormalities as well as a lower frequency of mutations involving NPM1, NRAS and FLT3 as compared with AML
without erythroid predominance. We conclude that the clinical, cytogenetic, and molecular features of AML with erythroid
predominance in the non-therapy-related setting are much closer to those of a high-grade myelodysplastic syndrome than
they are to other types of AML.
Ci
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