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a wkymvm-containing combination elicits potent anti-tumor activity in heterotopic cancer animal modelwkymvm-containing组合抒发强力的抗肿瘤活性的异位癌症动物模型
A WKYMVm-Containing Combination Elicits Potent Anti-
Tumor Activity in Heterotopic Cancer Animal Model
1,2 1,2 1 1,2 3 4
Sang Doo Kim , Ha Young Lee , Jae Woong Shim , Hak Jung Kim , Suk-Hwan Baek , Brian A. Zabel ,
Yoe-Sik Bae1,2*
1 Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea, 2 Mitochondria Hub Regulation Center, Dong-A University, Busan, South Korea,
3 Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea, 4 Palo Alto Institute for Research and Education, Veterans
Affairs Hospital, Palo Alto, California, United States of America
Abstract
The development of efficient anti-cancer therapy has been a topic of intense interest for several decades. Combined
administration of certain molecules and immune cells has been shown to be an effective form of anti-cancer therapy.
Here, we examined the effects of administering an immune stimulating peptide (WKYMVm), 5-fluoro-uracil (5-FU), and
mature dendritic cells (mDCs) against heterotopic cancer animal model. Administration of the triple combination
strongly reduced tumor volume in CT-26-inoculated heterotopic cancer animal model. The induced anti-tumor activity
was well correlated with FAS expression, caspase-3 activation, and cancer cell apoptosis. The triple combination
treatment caused recruitment of CD8 T lymphocytes and natural killer (NK) cells into the tumor. The production of two
cytokines, IFN-c and IL-12, were strongly stimulated by administration of the triple combination. Depletion of CD8 T
lymphocytes or NK cells by administration of anti-CD8 or
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