有哪些信誉好的足球投注网站acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of parkinsons disease针灸能增强突触多巴胺可用性改善运动机能帕金森病小鼠模型.pdfVIP
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acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of parkinsons disease针灸能增强突触多巴胺可用性改善运动机能帕金森病小鼠模型
Acupuncture Enhances the Synaptic Dopamine
Availability to Improve Motor Function in a Mouse Model
of Parkinson’s Disease
1,2 1 1 1 1 1
Seung-Nam Kim , Ah-Reum Doo , Ji-Yeun Park , Hyungjin Bae , Younbyoung Chae , Insop Shim ,
1 1 1 1
Hyangsook Lee , Woongjoon Moon *, Hyejung Lee , Hi-Joon Park *
1 Studies of Translational Acupuncture Research, Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Republic of Korea, 2 Department of
Oriental Medical Science, Kyung Hee University, Seoul, Republic of Korea
Abstract
Parkinson’s disease (PD) is caused by the selective loss of dopaminergic neurons in the substantia nigra (SN) and the
depletion of striatal dopamine (DA). Acupuncture, as an alternative therapy for PD, has beneficial effects in both PD patients
and PD animal models, although the underlying mechanisms therein remain uncertain. The present study investigated
whether acupuncture treatment affected dopamine neurotransmission in a PD mouse model using 1-methyl-4-phenyl-
1,2,3,6-tetrahydropyridine (MPTP). We found that acupuncture treatment at acupoint GB34 improved motor function with
accompanying dopaminergic neuron protection against MPTP but did not restore striatal dopamine depletion. Instead,
acupuncture treatment increased dopamine release that in turn, may lead to the enhancement of dopamine availability in
the synaptic cleft. Moreover, acupuncture treatment mitigated MPTP-induced abnormal postsynaptic changes, suggesting
that acupuncture treatment may increase postsynaptic dopamine neurotransmission and facilitate the normalization of
b
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