mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species溃疡分枝杆菌和其他mycolactone-producing分枝杆菌应该被视为一个单独的物种.pdfVIP
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mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species溃疡分枝杆菌和其他mycolactone-producing分枝杆菌应该被视为一个单独的物种
Viewpoints Mycobacterium ulcerans and Other Mycolactone- Producing Mycobacteria Should Be Considered a Single Species 1,2 3 ¨ 4,5 6 1,2 Sacha J. Pidot , Kingsley Asiedu , Michael Kaser , Janet A. M. Fyfe , Timothy P. Stinear * 1 Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia, 2 Department of Microbiology, Monash University, Clayton, Australia, 3 World Health Organization, Geneva, Switzerland, 4 Swiss Tropical and Public Health Institute, Basel, Switzerland, 5 University of Basel, Basel, Switzerland, 6 Victorian Infectious Diseases Reference Laboratory, North Melbourne, Australia The nomenclature of Mycobacterium ul- parisons have shown that these species common M. marinum progenitor [5,11,12] cerans has become confused with the share over 4,000 genes with 98.3% and have then diverged again into two discovery that other mycobacteria that average DNA sequence identity [2]. How- distinct lineages, with both lineages bear- are not necessarily associated with Buruli ever, there are also some important ing strains that cause Buruli ulcer [5,13] ulcer also produce the lipid toxin myco- genetic differences between them. DNA– (Figure 1). lactone. These mycobacteria—collectively DNA hybridisation (DDH) analysis con- The new species assignations for MPM known as mycolactone-producing myco- firmed their status as distinct species, as have not considered their genomic context bacteria (MPM)—have been given a inter-species relative hyb
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