有哪些信誉好的足球投注网站monitoring of human cytomegalovirus and virus-specific t-cell response in young patients receiving allogeneic hematopoietic stem cell transplantation监测人类巨细胞病毒和病毒特异性t细胞反应年轻接受同种异体造血干细胞移植的病人.pdfVIP
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monitoring of human cytomegalovirus and virus-specific t-cell response in young patients receiving allogeneic hematopoietic stem cell transplantation监测人类巨细胞病毒和病毒特异性t细胞反应年轻接受同种异体造血干细胞移植的病人
Monitoring of Human Cytomegalovirus and Virus- Specific T-Cell Response in Young Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation 1 1 2 2 2 Daniele Lilleri , Giuseppe Gerna *, Paola Zelini , Antonella Chiesa , Vanina Rognoni , 3 4 4 3,5 Angela Mastronuzzi , Giovanna Giorgiani , Marco Zecca , Franco Locatelli 1 Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 2 Struttura Semplice Virologia Molecolare, Struttura Complessa Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 3 Dipartimento di Oncoematologia Pediatrica, IRCCS Ospedale Pediatrico ` ` Bambino Gesu, Roma, Italy, 4 Struttura Complessa di Ematologia ed Oncologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 5 Universita di Pavia, Pavia, Italy Abstract In allogeneic hematopoietic stem-cell transplantation (HSCT) recipients, outcome of human cytomegalovirus (HCMV) infection results from balance between viral load/replication and pathogen-specific T-cell response. Using a cut-off of 30,000 HCMV DNA copies/ml blood for pre-emptive therapy and cut-offs of 1 and 3 virus-specific CD4+ and CD8+ T cells/ml blood for T-cell protection, we conducted in 131 young patients a prospective 3-year study aimed at verifying whether achievement of such immunological cut-offs protects from HCMV disease. In the first three months after transplantatio
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