mycolactone diffuses into the peripheral blood of buruli ulcer patients - implications for diagnosis and disease monitoring细菌内酯扩散到布鲁里溃疡患者的外周血,对诊断和疾病监测的影响.pdfVIP

Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease Monitoring 1. 2. 3 1,4 1 Fred S. Sarfo , Fabien Le Chevalier , N’Guetta Aka , Richard O. Phillips , Yaw Amoako , Ivo G. 5,6 7 3 8 2 Boneca , Pascal Lenormand , Mireille Dosso , Mark Wansbrough-Jones , Romain Veyron-Churlet , ´ 2 2 Laure Guenin-Mace , Caroline Demangel * ´ ´ ´ ´ ´ 1 Komfo Anokye Teaching Hospital, Kumasi, Ghana, 2 Institut Pasteur, Pathogenomique Mycobacterienne Integree, Paris, France, 3 Institut Pasteur, Mycobacteries ˆ ´ ´ Tuberculeuses et Atypiques, Abidjan, Cote d’Ivoire, 4 Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, 5 Institut Pasteur, Biologie et Genetique de ´ ´ la Paroi Bacterienne, Paris, France, 6 INSERM, Groupe AVENIR, Paris, France, 7 Institut Pasteur, Plateforme Proteomique, Paris, France, 8 St George’s University of London, London, United Kingdom Abstract Background: Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU), is unique among human pathogens in its capacity to produce a polyketide-derived macrolide called