monitoring of regulatory t cell frequencies and expression of ctla-4 on t cells, before and after dc vaccination, can predict survival in gbm patients监测调节性t细胞的频率和表达ctla-4 t细胞,dc疫苗接种前后,可以预测gbm患者的生存.pdfVIP

Monitoring of Regulatory T Cell Frequencies and Expression of CTLA-4 on T Cells, before and after DC Vaccination, Can Predict Survival in GBM Patients 1 1 2 1 1 1,3 Brendan Fong , Richard Jin , Xiaoyan Wang , Michael Safaee , Dominique N. Lisiero , Isaac Yang , Gang Li2,3, Linda M. Liau1,3,4, Robert M. Prins1,3,4,5* 1 Department of Neurosurgery, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America, 2 Department of Biostatistics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America, 3 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America, 4 Brain Research Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America, 5 Institute for Molecular Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America Abstract Purpose: Dendritic cell (DC) vaccines have recently emerged as an innovative therapeutic option for glioblastoma patients. To identify novel surrogates of anti-tumor immune responsiveness, we studied the dynamic expression of activation and inhibitory markers on peripheral blood lymphocyte (PBL) subsets in glioblastoma patients treated with DC vaccination at UCLA. Experimental Design: Pre-treatment and post-treatment PBL from 24 patients enrolled in two Phase I clinical trials of dendritic cell immunotherapy were stai