mycobacterium tuberculosis strains potentially involved in the tb epidemic in sweden a century ago结核分枝杆菌菌株可能参与结核病流行一个世纪前在瑞典.pdfVIP

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mycobacterium tuberculosis strains potentially involved in the tb epidemic in sweden a century ago结核分枝杆菌菌株可能参与结核病流行一个世纪前在瑞典.pdf

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mycobacterium tuberculosis strains potentially involved in the tb epidemic in sweden a century ago结核分枝杆菌菌株可能参与结核病流行一个世纪前在瑞典

Mycobacterium tuberculosis Strains Potentially Involved in the TB Epidemic in Sweden a Century Ago 1 1 1 1 1 Ramona Groenheit *, Solomon Ghebremichael , Alexandra Pennhag , Jerker Jonsson , Sven Hoffner , 2 1,3 2 ¨ 3 David Couvin , Tuija Koivula , Nalin Rastogi , Gunilla Kallenius 1 Department of Preparedness, Swedish Institute for Communicable Disease Control, Solna, Sweden, 2 Tuberculosis and Mycobacteria Unit, WHO Supranational TB ¨ Reference Laboratory, Institut Pasteur de la Guadeloupe, Guadeloupe, France, 3 Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden Abstract A hundred years ago the prevalence of tuberculosis (TB) in Sweden was one of the highest in the world. In this study we conducted a population-based search for distinct strains of Mycobacterium tuberculosis complex isolated from patients born in Sweden before 1945. Many of these isolates represent the M. tuberculosis complex population that fueled the TB epidemic in Sweden during the first half of the 20th century. Methods: Genetic relationships between strains that caused the epidemic and present day strains were studied by spoligotyping and restriction fragment length polymorphism. Results: The majority of the isolates from the elderly population were evolutionary recent Princ