monitoring bacterial burden, inflammation and bone damage longitudinally using optical and μct imaging in an orthopaedic implant infection in mice纵向监测细菌负担,炎症和骨损伤使用光学和μct成像在骨科植入物感染老鼠.pdfVIP

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monitoring bacterial burden, inflammation and bone damage longitudinally using optical and μct imaging in an orthopaedic implant infection in mice纵向监测细菌负担,炎症和骨损伤使用光学和μct成像在骨科植入物感染老鼠.pdf

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monitoring bacterial burden, inflammation and bone damage longitudinally using optical and μct imaging in an orthopaedic implant infection in mice纵向监测细菌负担,炎症和骨损伤使用光学和μct成像在骨科植入物感染老鼠

Monitoring Bacterial Burden, Inflammation and Bone Damage Longitudinally Using Optical and mCT Imaging in an Orthopaedic Implant Infection in Mice 1 2 1 3 2 Jared A. Niska , Jeffrey A. Meganck , Jonathan R. Pribaz , Jonathan H. Shahbazian , Ed Lim , 2 2 2,4 3 1 2 Ning Zhang , Brad W. Rice , Ali Akin , Romela Irene Ramos , Nicholas M. Bernthal , Kevin P. Francis , Lloyd S. Miller3* 1 Orthopaedic Hospital Research Center, Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America, 2 Caliper – a PerkinElmer Company, Alameda, California, United States of America, 3 Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 4 Novartis Institutes for BioMedical Research, Inc., Emeryville, California, United States of America Abstract Background: Recent advances in non-invasive optical, radiographic and mCT imaging provide an opportunity to monitor biological processes longitudinally in an anatomical context. One particularly relevant application for combining these modalities is to study orthopaedic implant infections. These infections are characterized by the formation of persistent bacterial biofilms on the implanted materials, causing inflammation, periprosthetic osteolysis, osteomyelitis, and bone damage, resulting in implant loosening and failure. Methodology/Principal Findings: An orthopaedic implant infection model was used in which a titanium Kirshner