有哪些信誉好的足球投注网站mycobacterium tuberculosis complex enhances susceptibility of cd4 t cells to hiv through a tlr2-mediated pathway结核分枝杆菌复合增强敏感性的cd4 t细胞通过tlr2-mediated通路艾滋病毒.pdfVIP
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mycobacterium tuberculosis complex enhances susceptibility of cd4 t cells to hiv through a tlr2-mediated pathway结核分枝杆菌复合增强敏感性的cd4 t细胞通过tlr2-mediated通路艾滋病毒
Mycobacterium tuberculosis Complex Enhances Susceptibility of CD4 T Cells to HIV through a TLR2- Mediated Pathway 1 1 1 1 1,2 Seema M. Thayil , Ya-Chi Ho , Robert C. Bollinger , Joel N. Blankson , Robert F. Siliciano , Petros C. Karakousis1,3*, Kathleen R. Page 1 1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3 Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America Abstract Among HIV-infected individuals, co-infection with Mycobacterium tuberculosis is associated with faster progression to AIDS. We investigated the hypothesis that M. bovis BCG and M. tuberculosis (Mtb complex) could enhance susceptibility of CD4+ cells to HIV infection. Peripheral blood mononuclear cells (PBMCs) collected from healthy donors were stimulated with M. bovis BCG, M. tuberculosis CDC1551 and M. smegmatis MC2 155, and stimulated CD4+ cells were infected with R5-and X4- tropic single replication-competent pseudovirus. CD4+ cells stimulated with Mtb complex showed enhanced infection with R5- and X4-tropic HIV, compared to unstimulated cells or cells stimulated with M. smegmatis (p,0.01). Treatment with TLR2 siRNA reversed the increased susceptibility of CD4+ cells with R5- and X4-tropic virus induced by Mtb complex. These findings suggest that TB infection and/or BCG vaccination may be a risk factor for HIV acquisition. Citation: Thayil SM, Ho Y-C, Bollinger RC, Blankson JN, Siliciano RF, et al. (2012) Mycobacterium tub
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