mycobacterium africanum—review of an important cause of human tuberculosis in west africa分枝杆菌的africanum-review人类肺结核在西非的一个重要原因.pdfVIP

Review Mycobacterium africanum—Review of an Important Cause of Human Tuberculosis in West Africa 1,2,3 1 4,5 Bouke C. de Jong *, Martin Antonio , Sebastien Gagneux 1 MRC Laboratories, Bacterial Diseases Programme, Fajara, The Gambia, 2 New York University Division of Infectious Diseases, New York, New York, United States of America, 3 Institute for Tropical Medicine, Mycobacteriology Unit, Antwerp, Belgium, 4 MRC National Institute for Medical Research, London, United Kingdom, 5 Swiss Tropical and Public Health Institute, Basel, Switzerland However, like M. bovis, M. africanum tended to be nitrate negative, a Abstract: Mycobacterium africanum consists of two weak producer of niacin, and to grow microaerophilically in media phylogenetically distinct lineages within the Mycobacteri- supplemented with pyruvate, albeit with variable results (Table 1, um tuberculosis complex, known as M. africanum West [8]). Meissner described similar isolates from Ghana in 1969 [9]. African 1 and M. africanum West African 2. These lineages On Lowenstein-Jensen solid agar, M. africanum grew more slowly are restricted to West Africa, where they cause up to half than M. tuberculosis, with cultures occasionally yielding growth only of human pulmonary tuberculosis. In this review we after 10 weeks, compared to 3–4 weeks in M. tuberculosis [10,11]. discuss the definition of M. africanum, describe the prevalence and restri