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myc localizes to histone locus bodies during replication in drosophilamyc定位组蛋白位点的身体在果蝇的复制
Myc Localizes to Histone Locus Bodies during Replication in Drosophila Kaveh Daneshvar, Abid Khan, Julie M. Goodliffe* Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America Abstract Myc is an important protein at the center of multiple pathways required for growth and proliferation in animals. The absence of Myc is lethal in flies and mice, and its over-production is a potent inducer of over-proliferation and cancer. Myc protein is localized to the nucleus where it executes its many functions, however the specific sub-nuclear localization of Myc has rarely been reported. The work we describe here began with an observation of unexpected, punctate spots of Myc protein in certain regions of Drosophila embryos. We investigated the identity of these puncta and demonstrate that Myc is co-localized with coilin, a marker for sub-nuclear organelles known as Cajal Bodies (CBs), in embryos, larvae and ovaries. Using antibodies specific for U7 snRNP component Lsm11, we show that the majority of Myc and coilin co-localization occurs in Histone Locus Bodies (HLBs), the sites of histone mRNA transcription and processing. Furthermore, Myc localizes to HLBs only during replication in mitotic and endocycling cells, suggesting that its role there relates to replication-dependent canonical histone gene transcription. These results provide evidence that sub-nuclear localization of Myc is cell-cycle dependent and potentially important for histone mRNA production and processing. Citation: Daneshvar K, Khan A, Goodliffe JM (2011) Myc Localizes to Histone Locus Bodies during Replication in Drosophila. PLoS ONE 6(8): e23928. doi:10.1371/ journal.pone.0023928 Editor: Marco Muzi-Falconi, Universita’ di Milano, Italy Received May 31, 2011; Accepted July 28, 2011; Published August 23, 2011
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