molecular tooth decay分子蛀牙.pdfVIP

Perspective Molecular Tooth Decay Rob DeSalle* American Museum of Natural History, New York, New York, United States of America Charles Darwin was intrigued with edentulous and enamelless mammals the vestigial organs and, in fact, made them ENAM genes are riddled with stop codons in a part of his ‘‘long argument’’ for the all three reading frames and several frame- existence of evolution in the natural world shifts exist in the gene sequences. The in Chapter 13 of On the Origin of Species. second major result the authors uncovered Now on the 150th anniversary of the required making two adjustments with how publication of that seminal work, a study phylogenetic and selection detection analy- linking vestigial organs with molecular ses are done. First, they took their phylogeny biology with paleontology has shown even and categorized branches in the tree into more clearly how vestigial organs are of four categories—functional, pre-mutation, critical explanatory power in evolutionary mixed (functional + pseudogene), and pseu- theory. In the current issue of PLoS dogene—by