有哪些信誉好的足球投注网站multiple var2csa-type pfemp1 genes located at different chromosomal loci occur in many plasmodium falciparum isolates多个var2csa-type pfemp1基因位于不同的染色体位点发生在许多恶性疟原虫分离.pdfVIP
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multiple var2csa-type pfemp1 genes located at different chromosomal loci occur in many plasmodium falciparum isolates多个var2csa-type pfemp1基因位于不同的染色体位点发生在许多恶性疟原虫分离
Multiple var2csa-Type PfEMP1 Genes Located at Different Chromosomal Loci Occur in Many Plasmodium falciparum Isolates 1 1 1 1 1,2 Adam F. Sander , Ali Salanti , Thomas Lavstsen , Morten A. Nielsen , Pamela Magistrado , John 2 3 1,4 Lusingu , Nicaise Tuikue Ndam , David E. Arnot * 1 Centre for Medical Parasitology, Department of International Health, Immunology Microbiology, Faculty of Health Sciences, University of Copenhagen Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark, 2 JMP-ENRICA Project, National Institute for Medical Research, Korogwe Laboratory, Tanga, Tanzania, 3 Institut de Recherche pour le Developpment, UR010, Universite Paris Descartes, Paris, France, 4 Institute of Immunology Infection Research, School of Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom Abstract Background: The var2csa gene encodes a Plasmodium falciparum adhesion receptor which binds chondroitin sulfate A (CSA). This var gene is more conserved than other PfEMP1/var genes and is found in all P. falciparum isolates. In isolates 3D7, FCR3/It4 and HB3, var2csa is transcribed from a sub-telomeric position on the left arm of chromosome 12, but it is not known if this location is conserved in all parasites. Genome sequencing indicates that the var2csa gene is duplicated in HB3, but whether this is true in natural populations is uncertain. Methodology/Principal Findings: To assess global variation in the VAR2CSA protein, sequence variation in the DBL2X region of var2csa genes in 54 P.falciparum samples w
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