multiple-clade h5n1 influenza split vaccine elicits broad cross protection against lethal influenza virus challenge in mice by intranasal vaccinationmultiple-clade h5n1流感疫苗分裂引发广泛的交叉保护致命的流感病毒在老鼠的挑战鼻内接种疫苗.pdfVIP

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multiple-clade h5n1 influenza split vaccine elicits broad cross protection against lethal influenza virus challenge in mice by intranasal vaccinationmultiple-clade h5n1流感疫苗分裂引发广泛的交叉保护致命的流感病毒在老鼠的挑战鼻内接种疫苗.pdf

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multiple-clade h5n1 influenza split vaccine elicits broad cross protection against lethal influenza virus challenge in mice by intranasal vaccinationmultiple-clade h5n1流感疫苗分裂引发广泛的交叉保护致命的流感病毒在老鼠的挑战鼻内接种疫苗

Multiple-Clade H5N1 Influenza Split Vaccine Elicits Broad Cross Protection against Lethal Influenza Virus Challenge in Mice by Intranasal Vaccination 1. 1. 2. 2 3 1 1 Penghui Yang , Yueqiang Duan , Peirui Zhang , Zhiwei Li , Cheng Wang , Mei Dong , Chong Tang , 1 1 1 4 2 1 Li Xing , Hongjing Gu , Zhongpeng Zhao , Xiufan Liu , Shaogeng Zhang *, Xiliang Wang * 1 Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China, 2 Department of Hepatobiliary, 302 Military Hospital, Beijing, China, 3 Medical College of Soochow University, Suzhou, China, 4 Key Laboratory for Animal Infectious Diseases of Ministry of Agriculture, Yangzhou University, Yangzhou, China Abstract Background: The increase in recent outbreaks and unpredictable changes of highly pathogenic avian influenza (HPAI) H5N1 in birds and humans highlights the urgent need to develop a cross-protective H5N1 vaccine. We here report our development of a multiple-clade H5N1 influenza vaccine tested for immunogenicity and efficacy to confer cross-protection in an animal model. Methodology/Principal Findings: Mice received two doses of influenza split vaccine with oil-in-water emulsion adjuvant SP01 by intranasal administration separated by two weeks. Single vaccines (3 mg HA per dose) included rg-A/Vietnam/1203/ 2004(Clade 1), rg-A/Indonesia/05/2005(Clade 2.1), and rg-A/Anhui/1/2005(Clade 2.3.4). The trivalent vaccine contained 1 mg HA per dose of each single vaccine. Importantly, complete cross-protection was observed in mice i