有哪些信誉好的足球投注网站multipotent capacity of immortalized human bronchial epithelial cells多功能永生化人支气管上皮细胞的能力.pdfVIP
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multipotent capacity of immortalized human bronchial epithelial cells多功能永生化人支气管上皮细胞的能力
Multipotent Capacity of Immortalized Human Bronchial Epithelial Cells 1 1 2 3 1 2 Oliver Delgado , Aadil A. Kaisani , Monica Spinola , Xian-Jin Xie , Kimberly G. Batten , John D. Minna , 1 1 Woodring E. Wright , Jerry W. Shay * 1 Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, 2 Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, 3 Department of Clinical Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas Texas, United States of America Abstract While the adult murine lung utilizes multiple compartmentally restricted progenitor cells during homeostasis and repair, much less is known about the progenitor cells from the human lung. Translating the murine stem cell model to humans is hindered by anatomical differences between species. Here we show that human bronchial epithelial cells (HBECs) display characteristics of multipotent stem cells of the lung. These HBECs express markers indicative of several epithelial types of the adult lung when experimentally tested in cell culture. When cultured in three different three-dimensional (3D) systems, subtle changes in the microenvironment result in unique responses including the ability of HBECs to differentiate into multiple central and peripheral lung cell types. These new findings indicate that the adult human lung contains a multipotent progenitor cell whose differentiation potential is primarily dictated by the microenvironment. The HBEC system is not only important in
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