monitoring cortical excitability during repetitive transcranial magnetic stimulation in children with adhd a single-blind, sham-controlled tms-eeg study重复经颅磁刺激期间监测大脑皮层兴奋性多动症儿童单盲,假对照tms-eeg研究.pdfVIP
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monitoring cortical excitability during repetitive transcranial magnetic stimulation in children with adhd a single-blind, sham-controlled tms-eeg study重复经颅磁刺激期间监测大脑皮层兴奋性多动症儿童单盲,假对照tms-eeg研究
Monitoring Cortical Excitability during Repetitive Transcranial Magnetic Stimulation in Children with ADHD: A Single-Blind, Sham-Controlled TMS-EEG Study 1,3 1 1 3 4 Christian Helfrich , Simone S. Pierau , Christine M. Freitag , Jochen Roeper , Ulf Ziemann , Stephan Bender1,2* 1 University Hospital for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University, Frankfurt/Main, Germany, 2 Section Clinical Neurophysiology and Multimodal Imaging, Child and Adolescent Psychiatric Hospital, Medical Faculty Carl-Gustav-Carus-University of Technology, Dresden, Germany, 3 Institute for Neurophysiology, Goethe University, Frankfurt/Main, Germany, 4 Department of Neurology and Stroke, Hertie-Institute for Clinical Brain Research, Eberhard- ¨ Karls-University, Tubingen, Germany Abstract Background: Repetitive transcranial magnetic stimulation (rTMS) allows non-invasive stimulation of the human brain. However, no suitable marker has yet been established to monitor the immediate rTMS effects on cortical areas in children. Objective: TMS-evoked EEG potentials (TEPs) could present a well-suited marker for real-time monitoring. Monitoring is particularly important in children where only few data about rTMS effects and safety are currently available. Methods: In a single-blind sham-controlled study, twenty-five school-aged children with ADHD received subthreshold 1 Hz- rTMS to the primary motor cortex. The TMS-evoked N100 was measured by 64-channel-EEG pre, during and post rTMS, and compared to sham stimulation as an intraindividual control condition. Results: TMS-evoked N100 amplitude decreased during 1 Hz-rTMS and, at the group level, reached a stable plateau after approximatel
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