human dendritic cells activated via dectin-1 are efficient at priming th17, cytotoxic cd8 t and b cell responses人类通过dectin-1树突状细胞激活有效地启动th17,细胞毒性cd8 t细胞和b细胞的反应.pdfVIP

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human dendritic cells activated via dectin-1 are efficient at priming th17, cytotoxic cd8 t and b cell responses人类通过dectin-1树突状细胞激活有效地启动th17,细胞毒性cd8 t细胞和b细胞的反应.pdf

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human dendritic cells activated via dectin-1 are efficient at priming th17, cytotoxic cd8 t and b cell responses人类通过dectin-1树突状细胞激活有效地启动th17,细胞毒性cd8 t细胞和b细胞的反应

Human Dendritic Cells Activated via Dectin-1 Are Efficient at Priming Th17, Cytotoxic CD8 T and B Cell Responses Sudhanshu Agrawal, Sudhir Gupta, Anshu Agrawal* Division of Basic and Clinical Immunology, Department of Medicine, University of California Irvine, Irvine, California, United States of America Abstract Background: Dendritic cells capture antigens through PRRs and modulate adaptive immune responses. The type of adaptive immune T cell response generated is dependent upon the type of PRR activated by the microbes. Dectin-1 is a C- type lectin receptor present on dendritic cells. Methodology/Principal Findings: Here we show that selective dectin-1 agonist Curdlan can activate human DCs and induce the secretion of large amounts of IL-23, IL-1b, IL-6 and low levels of IL-12p70 as determined by ELISA. The Curdlan- ¨ stimulated DCs are efficient at priming naıve CD4 cells to differentiate into Th17 and Th1 cells. Furthermore, these CD4 T cells induce differentiation of B cells to secrete IgG and IgA. In addition, Curdlan-stimulated DCs promote the expansion and differentiation of Granzyme and perforin expressing cytotoxic T lymphocyte that display high cytolytic activity against target tumor cells in vitro. Conclusions/Significance: These data demonstrate that DCs stimulated through Dectin-1 can generate efficient Th, CTL and B cell responses and can therefore be used as effective mucosal and systemic adjuvants in humans. Citation: Agrawal S, Gupta S, Agrawal A (2010) Human Dendritic Cells Activated via Dectin-1 Are Efficient at Priming Th17, Cytotoxic CD8 T and B Cell Responses. PLoS ONE 5(10): e13418. doi:10.1371/journal.pone.0013418 Editor: Fu-Sheng Wang, Beijing Institute of Infectious Diseases, China Received