hyper-activated pro-inflammatory cd16+ monocytes correlate with the severity of liver injury and fibrosis in patients with chronic hepatitis b超激活炎性cd16 +单核细胞与肝损伤的严重程度,在慢性乙型肝炎患者肝纤维化.pdfVIP

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hyper-activated pro-inflammatory cd16+ monocytes correlate with the severity of liver injury and fibrosis in patients with chronic hepatitis b超激活炎性cd16 +单核细胞与肝损伤的严重程度,在慢性乙型肝炎患者肝纤维化.pdf

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hyper-activatedpro-inflammatorycd16monocytescorrelatewiththeseverityofliverinjuryandfibrosisinpatientswithchronichepatitisb超激活炎性cd16单核细胞与肝损伤的严重程度,在慢性乙型肝炎患者肝纤维化

Hyper-Activated Pro-Inflammatory CD16+ Monocytes Correlate with the Severity of Liver Injury and Fibrosis in Patients with Chronic Hepatitis B 1. 2. 2 1 1 1 Ji-Yuan Zhang , Zheng-Sheng Zou , Ang Huang , Zheng Zhang , Jun-Liang Fu , Xiang-Sheng Xu , Li- 1 2 1 Ming Chen , Bao-Sen Li *, Fu-Sheng Wang * 1 Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China, 2 Department of Infectious Diseases, Beijing 302 Hospital, Beijing, China Abstract Background: Extensive mononuclear cell infiltration is strongly correlated with liver damage in patients with chronic hepatitis B virus (CHB) infection. Macrophages and infiltrating monocytes also participate in the development of liver damage and fibrosis in animal models. However, little is known regarding the immunopathogenic role of peripheral blood monocytes and intrahepatic macrophages. Methodology/Principal Findings: The frequencies, phenotypes, and functions of peripheral blood and intrahepatic monocyte/macrophage subsets were analyzed in 110 HBeAg positive CHB patients, including 32 immune tolerant (IT) carriers and 78 immune activated (IA) patients. Liver biopsies from 20 IA patients undergoing diagnosis were collected for immunohistochemical analysis. IA patients displayed significant increases in peripheral blood monocytes and intrahepatic macrophages as well as CD16+ subsets, which were closely associated with serum alanine aminotransferase (ALT) levels and the liver histological activity index (HAI) scores. In addition, the increa