hyperfunction of muscarinic receptor maintains long-term memory in 5-ht4 receptor knock-out mice毒蕈碱的受体保持长期记忆的机能亢进5-ht4受体小鼠.pdfVIP

Hyperfunction of Muscarinic Receptor Maintains Long-Term Memory in 5-HT4 Receptor Knock-Out Mice 1{ ´ 2 1 2 ´ 3 4 Luis Segu , Marie-Jose Lecomte , Mathieu Wolff , Julie Santamaria , Rene Hen , Aline Dumuis , Sylvie 2 ¨ 4 1 ´ 4 Berrard , Joel Bockaert , Marie-Christine Buhot , Valerie Compan * ´ 1 Centre de Neurosciences Integratives et Cognitives, CNRS UMR5228, Bordeaux University, Talence, France, 2 Centre de Recherche de l’Institut du Cerveau et de la Moelle ` Epiniere, CNRS UMR7225 INSERM UMR S975, Paris, France, 3 Center for Neurobiology and Behavior, Columbia University, New York, New York, United States of America, ´ ˆ 4 Institut de Genomique Fonctionnelle, Neurobiology, CNRS UMR5203 INSERM U661 Montpellier I II University, Nımes University, Montpellier, France Abstract Patients suffering from dementia of Alzheimer’s type express less serotonin 4 receptors (5-HTR ), but whether an absence of 4 these receptors modifies learning and memory is unexplored. In the spatial version of the Morris water maze, we show that 5-HTR4 knock-out (KO) and wild-type (WT) mice performed similarly for spatial learning, short- and long-term retention. Since 5-HTR control mnesic abilities, we tested whether cholinergic system had circumvented the absence of 5-HT