有哪些信誉好的足球投注网站hyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overloadhyperferritinemia与胰岛素抵抗和脂肪肝的病人没有铁过载.pdfVIP
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hyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overloadhyperferritinemia与胰岛素抵抗和脂肪肝的病人没有铁过载
Hyperferritinemia Is Associated with Insulin Resistance and Fatty Liver in Patients without Iron Overload 1 1,3 2,3 Robert Brudevold *, Torstein Hole , Jens Hammerstrøm 1 Department of Medicine, Aalesund Hospital, Aalesund, Norway, 2 Department of Medicine, St. Olavs Hospital, Trondheim, Norway, 3 Norwegian University of Science and Technology (NTNU), Trondheim, Norway Abstract Objective: During the last 10 years we have experienced an increasing number of referrals due to hyperferritinemia. This is probably due to increased awareness of hereditary hemochromatosis, and the availability of a genetic test for this condition. Most of these referred patients were over-weight middle-aged men with elevated ferritin levels, but without the hemochromatosis-predisposing gene mutations. We evaluated the relationship between hyperferritinemia and the metabolic syndrome in 40 patients. Methods: Forty consecutive patients referred for hyperferritinemia were investigated. The examination programme included medical history, clinical investigation and venous blood samples drawn after an overnight fast. This resulted in 34 patients with unexplained hyperferritinemia, which were further examined. Liver biopsy was successfully performed in 29 subjects. Liver iron stores were assessed morphologically, and by quantitative phlebotomy in 16 patients. Results: The majority of the patients had markers of the metabolic syndrome, and 18 patients (52%) fulfilled the IDF-criteria for the metabolic syndrome. Mean body mass index was elevated (28,8 64,2), mean diastolic blood pressure was 88,5 610,5 mmHg, and mean fasting insulin C-peptide pmol
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