有哪些信誉好的足球投注网站hypercholesterolemia is associated with the apolipoprotein c-iii (apoc3) genotype in children receiving haart an eight-year retrospective study高胆固醇血症与载脂蛋白相关c-iii(apoc3)基因型儿童接受haart八年回顾性研究.pdfVIP
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hypercholesterolemia is associated with the apolipoprotein c-iii (apoc3) genotype in children receiving haart an eight-year retrospective study高胆固醇血症与载脂蛋白相关c-iii(apoc3)基因型儿童接受haart八年回顾性研究
Hypercholesterolemia Is Associated with the Apolipoprotein C-III (APOC3) Genotype in Children Receiving HAART: An Eight-Year Retrospective Study 1 2 1,3 2 1,3 Carlos A. Rocco *, Debora Mecikovsky , Paula Aulicino , Rosa Bologna , Luisa Sen , Andrea Mangano1,3 ´ ´ ´ ´ 1 Laboratorio de Biologıa Celular y Retrovirus, Hospital de Pediatrıa ‘‘Juan P. Garrahan’’, Buenos Aires, Argentina, 2 Servicio de Epidemiologıa e Infectologıa, Hospital de ´ ´ ´ Pediatrıa ‘‘Juan P. Garrahan’’, Buenos Aires, Argentina, 3 Consejo Nacional de Investigaciones Cientıficas y Tecnicas (CONICET), Buenos Aires, Argentina Abstract Polymorphisms in apolipoprotein genes have shown to be predictors of plasma lipid levels in adult cohorts receiving highly active antiretroviral therapy (HAART). Our objective was to confirm the association between the APOC3 genotype and plasma lipid levels in an HIV-1-infected pediatric cohort exposed to HAART. A total of 130 HIV-1-infected children/ adolescents that attended a reference center in Argentina were selected for an 8-year longitudinal study with retrospective data collection. Longitudinal measurements of plasma triglycerides, total cholesterol, HDL-C and LDL-C were analyzed under linear or generalized linear mixed models. The contribution of the APOC3 genotype at sites 2482, 2455 and 3238 to plasma lipid levels prediction was tested after adjusting for potential confounders. Four major APOC3 haplotypes were observed for
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