hiv treatment as prevention considerations in the design, conduct, and analysis of cluster randomized controlled trials of combination hiv prevention艾滋病毒治疗和预防方面的考虑设计、行为,分析集群随机对照试验的艾滋病毒预防的结合.pdfVIP

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hiv treatment as prevention considerations in the design, conduct, and analysis of cluster randomized controlled trials of combination hiv prevention艾滋病毒治疗和预防方面的考虑设计、行为,分析集群随机对照试验的艾滋病毒预防的结合.pdf

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hiv treatment as prevention considerations in the design, conduct, and analysis of cluster randomized controlled trials of combination hiv prevention艾滋病毒治疗和预防方面的考虑设计、行为,分析集群随机对照试验的艾滋病毒预防的结合

Review HIV Treatment as Prevention: Considerations in the Design, Conduct, and Analysis of Cluster Randomized Controlled Trials of Combination HIV Prevention 1 ˆ ˆ 2 3 4,5 1 Marie-Claude Boily *, Benoıt Masse , Ramzi Alsallaq , Nancy S. Padian , Jeffrey W. Eaton , Juan F. Vesga1, Timothy B. Hallett1 1 Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom, 2 CHU Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada, 3 College of Nursing Global, New York University, New York, New York, United States of America, 4 Office of the US Global AIDS Coordinator, US Department of State, Washington, District of Columbia, United States of America, 5 Department of Epidemiology, University of California, Berkeley, California, United States of America ness or impact of combination prevention packages is difficult to Abstract: The rigorous evaluation of the impact of predict and needs to be rigorously evaluated in real world settings. combination HIV prevention packages at the population The impact of an intervention at the population level can be level will be critical for the future of HIV prevention. In this very different from its observed efficacy in clinical trials for many review, we discuss important considerations for the reasons, including differences in implementation (e.g., speed and design and interpretation of cluster randomized con-