hyperferritinemia and hyperuricemia may be associated with liver function abnormality in obese adolescentshyperferritinemia和高尿酸血可能与肝功能异常肥胖青少年.pdfVIP

Hyperferritinemia and Hyperuricemia May Be Associated with Liver Function Abnormality in Obese Adolescents 1,2 3 4 Solomon Chih Cheng Chen *, Ya Fang Huang , Jung Der Wang 1 Department of Pediatrics, Chia-Yi Christian Hospital, Chia-Yi City, Taiwan, 2 Department of Pediatrics, Medical College, Taipei Medical University, Taipei City, Taiwan, 3 Department of Clinical Laboratory, Pingtung Christian Hospital, Pingtung City, Taiwan, 4 Department of Public Health, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan Abstract Background: The iron status in human body and its association with liver function in adolescents was rarely studied. The objective was to investigate the association among the levels of serum ferritin, uric acid and alanine aminotransferase (ALT) in adolescents. Methods and Results: A total of 2090 adolescents negative for hepatitis B surface antigen from one junior high school (786, 12–13 years), three senior high schools (973, 15–16 years) and one college (331, 18–19 years) participated in this survey. Anthropometric and biochemical measurements, including complete blood count, ALT, serum ferritin and uric acid were performed. An ALT.42 U/L was defined as elevated, a ferritin level .200 mg/L was defined as hyperferritinemia. A uric acid level .460 mmol/L in males and .340 mmol/L in females was defined as hyperuricemia. The chi-squared test, linear regression and multivariate logistic regression were used for the data analysis. Elevated ALT levels were detected in 76 (3.6%) students and were more prevalent in males than females (6.4% vs. 2.0%, p,0.001). The univariate analysis found gender, age group, body mass index, ferritin level, uric acid level and white blood cel