hiv infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis a prospective observational study艾滋病毒感染发病率较低的收缩有关假定结核性心包炎前瞻性观察性研究.pdfVIP

HIV Infection Is Associated with a Lower Incidence of Constriction in Presumed Tuberculous Pericarditis: A Prospective Observational Study 1. 2. 3 1 1 Mpiko Ntsekhe , Charles S. Wiysonge , Freedom Gumedze , Gary Maartens , Patrick J. Commerford , 2,4 1 Jimmy A. Volmink , Bongani M. Mayosi * 1 Department of Medicine, University of Cape Town, Cape Town, South Africa, 2 South African Cochrane Centre, Medical Research Council, Cape Town, South Africa, 3 Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa, 4 Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Abstract Background: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotherapy. The impact of human immunodeficiency virus (HIV) infection on the incidence of constrictive pericarditis following tuberculous pericardial effusion is unknown. Methods and Results: We conducted a prospective observational study to determine the association between HIV infection and the incidence of constrictive pericarditis among 185 patients (median age 33 years) with suspected tuberculous pericardial effusion. These patients were recruited consecutively between March and October 2004 on commencement of anti-tuberculosis treatment, from 15 hospitals in Cameroon, Nigeria and South Africa. Surviving patients (N = 119) were assessed for clinical evidence of constrictive pericarditis at 3 and 6 months of follow-up. Clinical features of HIV infection were present in 42 (35.2%) of the 119 patients at enrolmen