hiv treatment as prevention models, data, and questions—towards evidence-based decision-making艾滋病毒治疗和预防模型、数据和questions-towards循证决策.pdfVIP

Review HIV Treatment as Prevention: Models, Data, and Questions—Towards Evidence-Based Decision-Making The HIV Modelling Consortium Treatment as Prevention Editorial Writing Group* antiretroviral therapy (ART) are much less likely to transmit the Abstract: Antiretroviral therapy (ART) for those infected infection to their heterosexual partners than those who are not. with HIV can prevent onward transmission of infection, This finding was shown in the HPTN 052 trial [11] (Box 1), which but biological efficacy alone is not enough to guide policy was chosen as the Science magazine breakthrough of the year for decisions about the role of ART in reducing HIV incidence. 2011 [12]. If viral load is fully suppressed, those on ART may Epidemiology, economics, demography, statistics, biolo- effectively be almost uninfectious. Although anticipated [13,14], gy, and mathematical modelling will be central in framing this finding has catalyzed enormous interest in how ART could key decisions in the optimal use of ART. PLoS Medicine, not only benefit the individual provided with the medicines, but with the HIV Modelling Consortium, has commissioned a also reduce the epidemic burden of the communities in which they set of articles that examine different aspects of HIV live by limiting HIV transmission.