hiv-1 clade d is associated with increased rates of cd4 decline in a kenyan cohorthiv - 1进化枝d与肯尼亚组增加cd4的利率下降.pdfVIP

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hiv-1 clade d is associated with increased rates of cd4 decline in a kenyan cohorthiv - 1进化枝d与肯尼亚组增加cd4的利率下降.pdf

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hiv-1 clade d is associated with increased rates of cd4 decline in a kenyan cohorthiv - 1进化枝d与肯尼亚组增加cd4的利率下降

HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort 1,2 3,4,5 1,2 6 7 Lyle R. McKinnon *, Nico J. Nagelkerke , Rupert Kaul , Souradet Y. Shaw , Rupert Capina , 3,7 2 3 2 2 2,8 Ma Luo , Anthony Kariri , Winnie Apidi , Makobu Kimani , Charles Wachihi , Walter Jaoko , A. Omu Anzala2,8, Joshua Kimani2,3, T. Blake Ball2,3,9, Francis A. Plummer2,3,7 1 Department of Medicine, University of Toronto, Toronto, Canada, 2 Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya, 3 Department of Medical Microbiology and 9 Immunology, University of Manitoba, Winnipeg, Canada, 4 Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands, 5 Community Medicine, United Arab Emirates University, Al Ain, United Arab Emirates, 6 Centre for Global Public Health, University of Manitoba, Winnipeg, Canada, 7 National Microbiology Lab, Public Health Agency of Canada, Winnipeg, Canada, 8 Kenyan AIDS Vaccine Initiative, Nairobi, Kenya, 9 Laboratory of HIV Immunology, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Abstract HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985–2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). Thi