helios expression is a marker of t cell activation and proliferation赫利俄斯的表情是t细胞的活化和增殖能力的一个标志.pdfVIP

Helios Expression Is a Marker of T Cell Activation and Proliferation 1 2 1 3 1 Tatiana Akimova , Ulf H. Beier , Liqing Wang , Matthew H. Levine , Wayne W. Hancock * 1 Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 2 Division of Nephrology, Department of Pediatrics, The Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 3 Department of Surgery, Penn Transplant Institute, Hospital of the University of Pennsylvania and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America Abstract Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune homeostasis. Over the past decade, Treg cells have become a major focus of research for many groups, and various functional subsets have been characterized. Recently, the Ikaros family member, Helios, was reported as a marker to discriminate naturally ¨ occurring, thymic-derived Tregs from those peripherally induced from naıve CD4+ T cells. We investigated Helios expression in ¨ murine and human T cells under resting or activating conditions, using well-characterized molecules of naıve/effector/memory