histone methylation analysis and pathway predictions in chickens after mdv infection组蛋白甲基化分析和多维距离特征向量之间路径预测在鸡感染.pdfVIP

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histone methylation analysis and pathway predictions in chickens after mdv infection组蛋白甲基化分析和多维距离特征向量之间路径预测在鸡感染.pdf

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histone methylation analysis and pathway predictions in chickens after mdv infection组蛋白甲基化分析和多维距离特征向量之间路径预测在鸡感染

Histone Methylation Analysis and Pathway Predictions in Chickens after MDV Infection 1. 1. 1 2,4 2 3 1¤ Juan Luo , Apratim Mitra , Fei Tian , Shuang Chang , Huanmin Zhang , Kairong Cui , Ying Yu , 3 1 Keji Zhao , Jiuzhou Song * 1 Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, United States of America, 2 United States Department of Agriculture, ARS, Avian Disease and Oncology Laboratory, East Lansing, Michigan, United States of America, 3 Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Department of Animal Science, Michigan State University, East Lansing, Michigan, United States of America Abstract Marek’s disease (MD) is a lymphoproliferative disease in chicken induced by Marek’s disease virus (MDV). Although studies have focused on the genetic differences between the resistant and susceptible chicken, less is known about the role of epigenetic factors in MD. In this study, genome-wide histone modifications in the non-MHC-associated resistant and susceptible chicken lines were examined. We found that tri-methylation at histone H3 Lys4 (H3K4me3) enrichment is positively correlated with the expression of protein coding genes as well as microRNA (miRNA) genes, whereas tri- methylation at histone H3 Lys27 (H3K27me3) exhibits a negative correlation. By identifying line-specific histone modifications in MDV infection, we found unique H3K4me3 islands in the resistant chicken activated