有哪些信誉好的足球投注网站helicobacter pylori icea, clinical outcomes, and correlation with caga a meta-analysis幽门螺杆菌icea、临床结果和相关caga荟萃分析.pdfVIP
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helicobacter pylori icea, clinical outcomes, and correlation with caga a meta-analysis幽门螺杆菌icea、临床结果和相关caga荟萃分析
Helicobacter pylori iceA, Clinical Outcomes, and Correlation with cagA: A Meta-Analysis 1,2 1,2 1,2 1 1 Seiji Shiota , Masahide Watada , Osamu Matsunari , Shun Iwatani , Rumiko Suzuki , Yoshio Yamaoka1,3* 1 Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Hasama-machi, Yufu-City, Oita, Japan, 2 Department of General Medicine, Oita University Faculty of Medicine, Hasama-machi, Yufu-City, Oita, Japan, 3 Department of Medicine-Gastroenterology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America Abstract Background: Although the iceA (induced by contact with epithelium) allelic types of Helicobacter pylori have been reported to be associated with peptic ulcer, the importance of iceA on clinical outcomes based on subsequent studies is controversial. The aim of this study was to estimate the magnitude of the risk for clinical outcomes associated with iceA. Methods: A literature search was performed using the PubMed and EMBASE databases for articles published through April 2011. Published case-control studies examining the relationship between iceA and clinical outcomes (gastritis, peptic ulcer, including gastric ulcer and duodenal ulcer, and gastric cancer) were included. Results: Fifty studies with a total of 5,357 patients were identified in the search. Infection with iceA1-positive H. pylori increased the overall risk for peptic ulcer by 1.26-fold (95% confidence interval [CI], 1.09–1.45). However, the test for heterogeneity was significant among these studies. Sensitivity analysis showed that the presen
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