有哪些信誉好的足球投注网站helicobacter suis causes severe gastric pathology in mouse and mongolian gerbil models of human gastric disease幽门螺杆菌是引起严重胃病理学在老鼠和人类胃疾病的长爪沙鼠模型.pdfVIP
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helicobacter suis causes severe gastric pathology in mouse and mongolian gerbil models of human gastric disease幽门螺杆菌是引起严重胃病理学在老鼠和人类胃疾病的长爪沙鼠模型
Helicobacter suis Causes Severe Gastric Pathology in Mouse and Mongolian Gerbil Models of Human Gastric Disease 1 1 1 2 3 Bram Flahou *, Freddy Haesebrouck , Frank Pasmans , Katharina D’Herde , Ann Driessen , Kim Van 1 1 4 1 1 Deun , Annemieke Smet , Luc Duchateau , Koen Chiers , Richard Ducatelle 1 Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium, 2 Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium, 3 Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands, 4 Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium Abstract Background: ‘‘Helicobacter (H.) heilmannii’’ type 1 is the most prevalent gastric non-H. pylori Helicobacter species in humans suffering from gastric disease. It has been shown to be identical to H. suis, a bacterium which is mainly associated with pigs. To obtain better insights into the long-term pathogenesis of infections with this micro-organism, experimental infections were carried out in different rodent models. Methodology/Principal Findings: Mongolian gerbils and mice of two strains (BALB/c and C57BL/6) were infected with H. suis and sacrificed at 3 weeks, 9 weeks and 8 months after infection. Gastric tissue samples were collected for PCR analysis, histological and ultrastructural examination. In gerbils, bacteria mainly colonized the antrum and a narrow zone in the fundus near the forestomach/stomach transition zone. In both mice strains, bacteria colo
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