helminth coinfection does not affect therapeutic effect of a dna vaccine in mice harboring tuberculosis寄生虫合并感染不影响治疗效果的dna疫苗在小鼠体内窝藏肺结核.pdfVIP

Helminth Coinfection Does Not Affect Therapeutic Effect of a DNA Vaccine in Mice Harboring Tuberculosis 1,2 ´ 2 1,2 1 Fabiani G. Frantz , Rogerio S. Rosada , Camila Peres-Buzalaf , Franciele R. T. Perusso , Vanderlei 2 2 3 ´ 2 ´ 1 Rodrigues , Simone G. Ramos , Steven L. Kunkel , Celio L. Silva , Lucia H. Faccioli * ˆ ˆ ˜ ˜ ˜ ˜ ˜ 1 Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 2 Faculdade de Medicina de Ribeirao Preto, ˜ ˜ ˜ Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 3 Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America Abstract Background: Helminthiasis and tuberculosis (TB) coincide geographically and there is much interest in exploring how concurrent worm infections might alter immune responses against bacilli and might necessitate altered therapeutic approaches. A DNA vaccine that codifies heat shock protein Hsp65 from M. leprae (DNAhsp65) has been used in therapy during experimental tuberculosis. This study focused on the impact of the co-existence of worms and TB on the therapeutic effects of DNAhsp65. Methodology/Principal Findings: Mice were infected with Toxocara canis or with Schistosoma mansoni, followed by coinfection with M. tuberculos