high acsl5 transcript levels associate with systemic lupus erythematosus and apoptosis in jurkat t lymphocytes and peripheral blood cells高acsl5转录水平与系统性红斑狼疮和jurkat t淋巴细胞和外周血细胞的细胞凋亡.pdfVIP

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high acsl5 transcript levels associate with systemic lupus erythematosus and apoptosis in jurkat t lymphocytes and peripheral blood cells高acsl5转录水平与系统性红斑狼疮和jurkat t淋巴细胞和外周血细胞的细胞凋亡.pdf

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high acsl5 transcript levels associate with systemic lupus erythematosus and apoptosis in jurkat t lymphocytes and peripheral blood cells高acsl5转录水平与系统性红斑狼疮和jurkat t淋巴细胞和外周血细胞的细胞凋亡

High ACSL5 Transcript Levels Associate with Systemic Lupus Erythematosus and Apoptosis in Jurkat T Lymphocytes and Peripheral Blood Cells ´ 1. 1. 2 . 1. Antonio Catala-Rabasa , Dorothy Ndagire , Jose Mario Sabio * , Maria Fedetz , Fuencisla 1 . 1 . Matesanz * , Antonio Alcina * ´ ´ ´ 1 Department of Cell Biology and Immunology, Instituto de Parasitologıa y Biomedicina ‘‘Lopez Neyra’’- Consejo Superior de Investigaciones Cientıficas (IPBLN-CSIC), ´ Granada, Spain, 2 Unidad de Enfermedades Autoinmunes Sistemicas, Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, Spain Abstract Background: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease in which increased apoptosis and decreased apoptotic cells removal has been described as most relevant in the pathogenesis. Long-chain acyl-coenzyme A synthetases (ACSLs) have been involved in the immunological dysfunction of mouse models of lupus-like autoimmunity and apoptosis in different in vitro cell systems. The aim of this work was to assess among the ACSL isoforms the involvement of ACSL2, ACSL4 and ACSL5 in SLE pathogenesis. Findings: With this end, we determined the ACSL2, ACSL4 and ACSL5 transcript levels in peripheral blood mononuclear cells (PBMCs) of 45 SLE patients and 49 healthy controls by quantitative real time-PCR (q-PCR). We found that patients with SLE had higher ACSL5 transcript levels than healthy controls [median (