glutathione s-transferase m1 gene polymorphism and laryngeal cancer risk a meta-analysis谷胱甘肽s-transferase m1基因多态性和喉癌荟萃分析的风险.pdfVIP
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glutathione s-transferase m1 gene polymorphism and laryngeal cancer risk a meta-analysis谷胱甘肽s-transferase m1基因多态性和喉癌荟萃分析的风险
Glutathione S-Transferase M1 Gene Polymorphism and Laryngeal Cancer Risk: A Meta-Analysis 1 1 . 1 1 1 2 . Xin-Jiang Ying *, Pin Dong * , Bin Shen , Cheng-Zhi Xu , Hong-Ming Xu , Shu-Wei Zhao * 1 Department of Otolaryngology-Head and Neck Surgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2 Department of Otolaryngology, Changzheng Hospital, Second Military Medical University, Shanghai, China Abstract Background and Objectives: Studies investigating the association between glutathione S-transferase M1 (GSTM1) gene polymorphism and laryngeal cancer risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible associations of GSTM1 gene polymorphism with laryngeal cancer risk. Methods: The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure until May 2011 and selected on the basis of the established inclusion criteria for publications, then a meta-analysis was performed to quantitatively summarize association of GSTM1 polymorphism with laryngeal cancer susceptibility. Results: Seventeen studies were included in the present meta-analysis (2,180 cases and 2,868 controls). The combined results based on all studies showed that GSTM1 null genotype was associated with increased laryngeal cancer risk (OR = 1.17, 95% CI = 1.04,1.31). When stratifying for race, GSTM1 null genotype exhibited increased laryngeal cancer risk in Caucasians (OR = 1.15, 95% CI = 1.01,1.31), while no significant association was detected i
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