有哪些信誉好的足球投注网站heterosubtypic antibody response elicited with seasonal influenza vaccine correlates partial protection against highly pathogenic h5n1 virusheterosubtypic抗体反应与季节性流感疫苗引起相关部分防止高致病性h5n1病毒.pdfVIP
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heterosubtypic antibody response elicited with seasonal influenza vaccine correlates partial protection against highly pathogenic h5n1 virusheterosubtypic抗体反应与季节性流感疫苗引起相关部分防止高致病性h5n1病毒
Heterosubtypic Antibody Response Elicited with Seasonal Influenza Vaccine Correlates Partial Protection against Highly Pathogenic H5N1 Virus 1. 1. 1 2 2 1 Heng Ding , Cheguo Tsai , Fan Zhou , Philippe Buchy , Vincent Deubel , Paul Zhou * 1 Unit of Anti-Viral Immunity and Genetic Therapy, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, 2 Institut Pasteur in Cambodia, Phnom Penh, Cambodia Abstract Background: The spread of highly pathogenic avian influenza (HPAI) H5N1 virus in human remains a global health concern. Heterosubtypic antibody response between seasonal influenza vaccine and potential pandemic influenza virus has important implications for public health. Previous studies by Corti et al. and by Gioia et al. demonstrate that heterosubtypic neutralizing antibodies against the highly pathogenic H5N1 virus can be elicited with a seasonal influenza vaccine in humans. However, whether such response offers immune protection against highly pathogenic H5N1 virus remained to be determined. Methodology/Principal Findings: In this study, using a sensitive influenza HA (hemagglutinin) and NA (neuraminidase) pseudotype-based neutralization (PN) assay we first confirmed that low levels of heterosubtypic neutralizing antibody response against H5N1 virus were indeed elicited with seasonal influenza vaccine in humans. We then immunized mice with the seasonal influenza vaccine and challenged them with lethal doses of highly pathogenic H5N1 virus. As controls, we immunized mice with homosubtypic H5N1 virus like particles (VLP) or PBS and challenged them with the same H5N1 virus. He
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