有哪些信誉好的足球投注网站heterosexual and homosexual partners practising unprotected sex may develop allogeneic immunity and to a lesser extent tolerance异性恋和同性恋伙伴练习无保护措施的性行为可能产生同种异体免疫和一定程度上的宽容.pdfVIP
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heterosexual and homosexual partners practising unprotected sex may develop allogeneic immunity and to a lesser extent tolerance异性恋和同性恋伙伴练习无保护措施的性行为可能产生同种异体免疫和一定程度上的宽容
Heterosexual and Homosexual Partners Practising Unprotected Sex May Develop Allogeneic Immunity and to a Lesser Extent Tolerance 1 2 1 2 1 Cherry Kingsley , Barry Peters , Kaboutar Babaahmady , Laura Pomeroy , Durdana Rahman , Robert 3 1 Vaughan , Thomas Lehner * 1 Mucosal Immunology Unit, Kings College London, Guy’s Hospital, London, United Kingdom, 2 Department of Infectious Diseases, Kings College London, London, United Kingdom, 3 Department of Tissue Typing, Kings College London, Guy’s Hospital, London, United Kingdom Abstract Background: Epidemiological studies suggest that allogeneic immunity may inhibit HIV-1 transmission from mother to baby and is less frequent in multiparous than uniparous women. Alloimmune responses may also be elicited during unprotected heterosexual intercourse, which is associated ex vivo with resistance to HIV infection. Methodology/Principal Findings: The investigation was carried out in well-defined heterosexual and homosexual monogamous partners, practising unprotected sex and a heterosexual cohort practising protected sex. Allogeneic CD4+ and CD8+ T cell proliferative responses were elicited by stimulating PBMC with the partners’ irradiated monocytes and compared with 3rd party unrelated monocytes, using the CFSE method. Significant increase in allogeneic proliferative responses was found in the CD4+ and CD8+ T cells to the partners’ irradiated monocytes, as compared with 3rd party unrelated monocytes (p#0.001). However, a significant decrease in proliferative responses, especially of CD8+ T cells to the partners’ compared with 3rd party monocytes was consistent with tolerization, in both the heterosexual
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