global transcriptional response to hfe deficiency and dietary iron overload in mouse liver and duodenum全球转录反应hfe不足和饮食铁过载在小鼠肝脏和十二指肠.pdfVIP

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global transcriptional response to hfe deficiency and dietary iron overload in mouse liver and duodenum全球转录反应hfe不足和饮食铁过载在小鼠肝脏和十二指肠.pdf

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global transcriptional response to hfe deficiency and dietary iron overload in mouse liver and duodenum全球转录反应hfe不足和饮食铁过载在小鼠肝脏和十二指肠

Global Transcriptional Response to Hfe Deficiency and Dietary Iron Overload in Mouse Liver and Duodenum 1 2 3,4,5 5,6 5,6 Alejandra Rodriguez *, Tiina Luukkaala , Robert E. Fleming , Robert S. Britton , Bruce R. Bacon , Seppo Parkkila1,7 1 Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, 2 Science Center, Pirkanmaa Hospital District and Tampere School of Public Health, University of Tampere, Tampere, Finland, 3 Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, 4 Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, 5 Saint Louis University Liver Center, St. Louis, Missouri, United States of America, 6 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America, 7 School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland Abstract Iron is an essential trace element whose absorption is usually tightly regulated in the duodenum. HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the iron-regulatory hormone, hepcidin, which results in increased iron absorption. The liver is crucial for iron homeostasis as it is the main production site of hepcidin. The aim of this study was to explore and compare the genome-wide transcriptome response to Hfe deficiency and dietary iron overload in murine liver and duodenum. IlluminaTM arrays containing over 47,000 probes were used