guillain-barré syndrome-related campylobacter jejuni in bangladesh ganglioside mimicry and cross-reactive antibodies格林-巴利syndrome-related空肠弯曲杆菌在孟加拉国神经节苷脂拟态和可交叉反应的抗体.pdfVIP
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guillain-barré syndrome-related campylobacter jejuni in bangladesh ganglioside mimicry and cross-reactive antibodies格林-巴利syndrome-related空肠弯曲杆菌在孟加拉国神经节苷脂拟态和可交叉反应的抗体
´ Guillain-Barre Syndrome-Related Campylobacter jejuni in Bangladesh: Ganglioside Mimicry and Cross-Reactive Antibodies 1,2 3 4 5 3 5 Zhahirul Islam *, Michel Gilbert , Quazi D. Mohammad , Kevin Klaij , Jianjun Li , Wouter van Rijs , 5 1 6 2 1,2 Anne P. Tio-Gillen , Kaisar A. Talukder , Hugh J. Willison , Alex van Belkum , Hubert P. Endtz , Bart C. Jacobs5 1 Emerging Diseases and Immunobiology, Centre for Food and Waterborne Diseases, icddr,b, Dhaka, Bangladesh, 2 Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands, 3 National Research Council Canada, Ottawa, Ontario, Canada, 4 Department of Neurology, Dhaka Medical College Hospital, Dhaka, Bangladesh, 5 Neurology and Immunology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands, 6 College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom Abstract ´ Background: Campylobacter jejuni is the predominant antecedent infection in Guillain-Barre syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C. jejuni lipo-oligosaccharides (LOS) precipitate the development of GBS, although this mechanism has not been established in patients from developing countries. We determined the carbohydrate mimicry between C. jejuni LOS and gangliosides, and the cross-reactive antibody response in
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