genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity基因组雄激素receptor-occupied与不同的功能区域,定义的组蛋白乙酰化作用,coregulators和转录能力.pdfVIP

Genomic Androgen Receptor-Occupied Regions with Different Functions, Defined by Histone Acetylation, Coregulators and Transcriptional Capacity 1,2,5. 8. 3,6 7 3,6 1,5 Li Jia , Benjamin P. Berman , Unnati Jariwala , Xiting Yan , Jon P. Cogan , Allison Walters , 7 1 3,4,6 1,2,5 Ting Chen , Grant Buchanan , Baruch Frenkel *, Gerhard A. Coetzee * 1 Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America, 2 Department of Urology, University of Southern California, Los Angeles, California, United States of America, 3 Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, United States of America, 4 Department of Orthopedic Surgery, University of Southern California, Los Angeles, California, United States of America, 5 Norris Cancer Center, University of Southern California, Los Angeles, California, United States of America, 6 Institute of Genetic Medicine, University of Southern California, Los Angeles, California, United States of America, 7 Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America, 8 Epigenome Center, Keck School of Medicine, Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, United States of America Abstract Background: The androgen receptor (AR) is a steroid-activated transcription factor that binds at specific DNA locations and plays a key role in the etiology of prostate cancer. While numerous studies have iden